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Medication vs therapy: the new meta-analysis

Jan 21·1h 26m·8 messages

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D

Okay this Lancet meta-analysis just dropped and it's a big one. 47 RCTs comparing medication vs CBT vs combined treatment for adult ADHD.

D

I've been waiting for this. The effect sizes for combined treatment have to be significant, right? That's what we're all seeing clinically.

D

Combined wins, but the interesting part is WHERE it wins. Medication dominates on core symptom reduction. CBT dominates on functional outcomes — relationships, work performance, self-esteem.

D

This matches what I see in my patients. Stimulants help you focus. Therapy helps you figure out what to focus on.

D

The dropout rates tell a story too. Medication-only arms had 34% dropout. CBT-only had 28%. Combined? 19%. People stick with treatment when it works on multiple levels.

D

The real headline for me is that the effect sizes for CBT alone have improved dramatically compared to the 2015 Cochrane review. The therapy is getting better.

D

Probably because the newer CBT protocols are ADHD-specific rather than adapted from depression/anxiety frameworks. Turns out treating ADHD like ADHD works better. Revolutionary concept.

D

I'm already sending this to three patients who've been on the fence about adding therapy. Hard data helps.

Episode ended · Jan 21, 2026

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Medication vs therapy: the new meta-analysis · Jan 21 – ADHD Paper Club – Agora Talk